Dom D’Agostino — The Power of the Ketogenic Diet

Dom D'Agostino
“If medicine wants to focus on prevention, there’s no better tool than nutrition.”

– Dominic D’Agostino

Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.

Many of you sent enthusiastic follow-up questions after the last conversation we had, so Dom took the time to answer your most popular questions. In particular, he focused on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).

It takes a few minutes for Dom to warm up — so be patient! If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.

If you only have 5 minutes, listen to Dom’s thoughts on how much protein you should eat on a ketogenic diet.


Want to hear my first interview with Dom D’Agostino? — Listen to our in-depth conversation here. In this episode, we discuss fasting, heavy deadlifts, and the end of cancer (stream below or right-click here to download):

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QUESTION(S) OF THE DAY: What was your favorite quote or lesson from this episode? Please let me know in the comments.

Scroll below for links and show notes…

Selected Links from the Episode

  • Connect with Dom D’Agostino:

Show Notes

  • Why is there so much resistance among dieticians and researchers toward ketosis despite evidence in its favor? [07:12]
  • Can you gain muscle size and strength on a ketogenic diet? [15:20]
  • How much protein should you take in with a ketogenic diet? [16:21]
  • What is the impact of the ketogenic diet on Type 1 diabetes? [19:16]
  • Is it better to analyze ketone production by breath or blood? [27:42]
  • How does ketosis affect performance at altitude? [30:53]
  • Are there any differences females need to be aware of when considering a ketogenic diet? [35:53]
  • Can a female obtain a sub-10 percent body fat with a ketogenic diet? [40:43]
  • How does ketosis affect the microbiota? [44:53]
  • Is counting calories just as important as tracking fat intake and carb restriction if you want to avoid weight gain? [52:00]
  • What are Dom’s nutritional tricks to surviving scientific conferences where the food is often less than healthy? [55:36]
  • What stimulants aid in ketosis? [58:53]
  • Can a vegetarian or vegan follow a ketogenic diet? [1:05:01]
  • Should you be concerned if a ketogenic diet increases your LDL or LDL-P (bad cholesterol)? [1:08:55]
  • Elevated triglycerides? A ketogenic diet isn’t for everyone. [1:14:17]
  • Is it dangerous to use ketone salts? [1:15:29]
  • What’s Dom’s advice for people suffering from fatty acid oxidation disorders? [1:24:39]
  • Does Dom really support Kegenix? [1:29:40]
  • What are Dom’s go-to products? [1:37:21]
  • Are exogenous ketones only useful in a state of ketosis, or would they benefit someone who is not keto-adapted? [1:45:28]
  • Can exogenous ketones combined with a low-carb diet (but not a ketogenic diet) still give some or all of the benefits of a strict ketogenic diet? [1:48:38]

People Mentioned

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Who was interviewed? Here’s a very partial list: tech icons (founders of Facebook, Twitter, LinkedIn, Craigslist, Pinterest, Spotify, Salesforce, Dropbox, and more), Jimmy Fallon, Arianna Huffington, Brandon Stanton (Humans of New York), Lord Rabbi Jonathan Sacks, Ayaan Hirsi Ali, Ben Stiller, Maurice Ashley (first African-American Grandmaster of chess), Brené Brown (researcher and bestselling author), Rick Rubin (legendary music producer), Temple Grandin (animal behavior expert and autism activist), Franklin Leonard (The Black List), Dara Torres (12-time Olympic medalist in swimming), David Lynch (director), Kelly Slater (surfing legend), Bozoma Saint John (Beats/Apple/Uber), Lewis Cantley (famed cancer researcher), Maria Sharapova, Chris Anderson (curator of TED), Terry Crews, Greg Norman (golf icon), Vitalik Buterin (creator of Ethereum), and nearly 100 more. Check it all out by clicking here. is a news aggregation service that brings you best of world articles to you for your consumption.

Author: Tim Ferriss
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